Pengaruh Pemberian Ketorolak dan Parecoxib Iintramuskuler Terhadap Gambaran Histopatologi Tubulus Proksimal Ginjal Tikus Wistar
ABSTRACT
Background: Nonsteroid Anti inflammation drugs has role in controlling inflammation through COX-1 and COX -2 inhibition. Ketorolac is one of COX
inhibitor non selective that widely used, meanwhile Parecoxib is one of the newest drugs of COX-2 selective inhibitor. Both of the drugs mainly used as analgetics that have metabolit elimination in the kidneys, which has risk to cause renal cell injury especially in the proxymal tubuli. The changes of renalis structure can be observed from microscopic evaluation, including inflammation reaction, cell degenerative, necrosis and even cell fibrosis.
Objectives : To observed the changes in histopathology proxymal tubuli renal of wistar rats after given ketorolac and parecoxib intramuscular.
Methods : we’re conducting an experimental laboratoric research using randomized post test control group design with the population of 21 male wistar rats, devided into 3 randomized group, which consist of 7 wistar rats givien incision wounds each group. The 1st group which was the control group (I) were not given any medication, The 2nd group (K) were given 0,54 mg intramuscular ketorolac every 8 hours for 5 days, while the 3rd group (P) were given 0,72 mg parecoxib intramuscular every 12 hours for 5 days. After 5 days, we observed the histopthology structure of the rats in each groups. The data were analyzed statistically using Kruskal Wallis and Mann-Whitney test.
Results: There’s significants results in all variables. The p values for first group (I) compare with second group (K) are 0,002 ; first group (I) with third group (P) (p=0,007) ; second group (K) to third group (P) with p values 0,002.
Conclution: from the result we conclude that based on histopathologic proximal tubuli findings, rats which were given ketorolac had more significant changes compare with control group and rats that were given parecoxib.
Keywords : ketorolac, parecoxib, histopathology proxymal tubuli renal
ABSTRAK
Latar Bekakang: Obat anti inflamasi non steroid (OAINS) berperan dalam mengendalikan inflamasi melalui inhibisi COX 1 dan COX 2.Ketorolak merupakan salah satu non selektif inhibitor COX yang sudah luas penggunaannya. Parecoxib merupakan inhibitor COX-2 selektif yang lebih baru.Ketorolak dan parecoxib sebagai analgesik yang sering dipakai eliminasi metabolitnya di ginjal.Pada batas-batas tertentu ginjal tidak
dapat melakukan fungsinya dalam eliminasi obat sehingga menyebabkan cedera sel ginjal, terutama daerah tubulus proksimal. Perubahan struktur yang terjadi akibat kerusakan tersebut dapat diamati dari gambaran mikroskopis cedera sel yang dapat meliputi reaksi inflamasi, degenerasi, nekrosis bahkan fibrosis.
Tujuan: Mengetahui pengaruh pemberian ketorolak dan parecoxib intramuscular terhadap gambaran histopatogi tubulus proksimal ginjal tikus wistar.
Metode: Dilakukan penelitian eksperimental laboratorik menggunakan randomized post test control group design pada 21 ekor tikus wistar jantan yang dibagi menjadi 3 kelompok secara acak masing- masing kelompok terdiri dari 7 ekor tikus wistar yangdiberi luka incisi.Kelompok kontrol (I) tidak mendapat ketorolak dan parecoxib,Kelompok I (K) mendapat ketorolak dengan dosis 0,54mg IM tiap 8 jam, Kelompok II (P) mendapat parecoxib 0,72mg IMtiap 12 jam selama 5 hari dan dilakukan terminasi serta pengambilan jaringan ginjal.Analisa statistik data tidak normal
menggunakan uji statistik Kruskal Wallis lalu dilanjutkan dengan uji statistik Mann-Whitney.
Hasil: Nilai p antara kelompok I terhadap kelompok K = 0,002, terdapat perbedaan bermakna antara I dan K, nilai p antara kelompok I dan kelompok P = 0,007 terdapat perbedaan bermakna antara I dan P, sedangkan nilai p antara kelompok K dan P = 0,002 maka terdapat perbedaan bermakna antara K dan P.
Kesimpulan: Ketorolak lebih merusak ginjal secara gambaran histopatologi tubulus proksimal dibandingkan dengan kontrol dan parecoxib.
Kata kunci : Ketorolak, Parecoxib, Gambaran histopatologi tubulus proksimal ginjal
Artikel Sekarang
Dipublikasi pada 01 July 2014
Penulis :
» Jerry Ferdinand
» Nur Hajriya Brahmani
» Himawan Sasongko
Kategori : Penelitian
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Volume VI Nomor 2, Juli 2014 Cover JAI
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