Pengaruh Pemberian Minuman Karbohidrat Dan Protein Whey Pra Operasi Terhadap Kadar C- Reactive Protein Pasca Operasi Pada Pasien Mastektomi
ABSTRACT

Background: CRP is an acute phase protein levels in the blood are intimately associated with the acute inflammatory response that occurs. Surgery and prolonged fasting causes release of pro inflammatory cytokines and acute phase inflammatory mediators through a complex process

Objective: To prove that preoperative carbohydrate and whey protein drinks effects the postoperative CRP levels in mastectomy patients

Methods: It is a randomized controlled trial study. 26 samples are divided into two groups. The treatment group (13 samples) was given 400 mL of carbohydrate and whey protein drinks the night before surgery and 200 mL 4 hours before surgery. The control group was given mineral water with the same amount and timing  as the treatment group. Both groups were examined pre- and postoperative CRP levels.

Results: There were significant differences (p = 0.001) in postoperative CRP levels between the control group (7,62 ± 2,074) compared to postoperative CRP in treatment group ( 2,81 ± 2,920). There is also a significant difference (p = 0.000) in the difference between preoperative and postoperative CRP levels in the control group (5,36 ± 0,53) compared to the treatment group CRP (0,89 ± 0,938).

Conclusion: Preoperative carbohydrate and whey protein drinks loading has been prooved to reduce postoperative acute phase inflammatory response, which explains the increase of lower postoperative CRP levels in the treatment group compared to postoperative CRP levels in control group.

 

Keywords : CRP, acute inflammatory response, carbohydrate and whey protein drinks loading
ABSTRAK

Latar belakang : CRP adalah protein fase akut yang kadarnya dalam darah sangat berkaitan erat dengan respon inflamasi akut yang terjadi.Tindakan pembedahan dan puasa yang berkepanjangan menyebabkan pelepasan sitokin-sitokin  proinflamasi dan  mediator inflamasifaseakut melalui proses yang rumit.

Tujuan : Membuktikan pengaruh pemberian minuman karbohidrat dan protein whey praoperasi terhadap kadar CRP pascaoperasi pada pasien mastektomi.

Metode : Penelitian jenis uji klinis acak terkontrol. Sampel penelitian sebanyak 26 dibagi menjadi 2 kelompok. Kelompok perlakuan (13 sampel) diberikan 400 mL minuman karbohidrat dan protein whey malam sebelum operasi dan 200 mL 4 jam sebelum operasi. Kelompok kontrol diberikan air mineral dengan jumlah dan waktu pemberian yang sama dengan kelompok perlakuan. Kedua kelompok diperiksa kadar CRP pra dan pascaoperasi.

Hasil : Terdapat perbedaan bermakna ( p = 0,001) pada kadarCRP pascaoperasi antara kelompok kontrol yaitu 7,62 ± 2,074 dibandingkan dengan CRP pascaoperasi kelompok perlakuan yaitu 2,81 ± 2,920. Selain itu juga terdapat perbedaan yang bermakna (p = 0,000) dalam selisih kadar CRP praoperasi dan pascaoperasi pada kelompok kontrol yaitu 5,36 ± 0,535 dibandingkan dengan kelompok perlakuan yaitu 0,89 ± 0,938.

Kesimpulan : Pemberian minuman karbohidrat dan protein whey pra operasi terbukti menurunkan respon inflamasi fase akut pascaoperasi, yang tergambar dari peningkatan kadar CRP pascaoperasi yang lebih rendah pada kelompok perlakuan dibandingkan dengan kelompok kontrol.

 

Kata kunci : CRP, respon inflamasi akut, pemberian minuman karbohidrat dan protein
Artikel Sekarang
Dipublikasi pada 01 March 2015
Penulis :
» Erwin Santoso Andreanto
» Aria Dian Primatika
» Jati Listiyanto Pujo
Kategori : Penelitian
Berkas Artikel (PDF)
Dari Jurnal
Volume VII Nomor 1, Maret 2015 Cover JAI
Daftar Isi | Berkas Full (PDF)

 

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