Pengaruh Lidokain Intravena Terhadap Kadar Superoxide Dismutase 1 (Sod-1) Paru Kelinci Dengan Lung Ischemic Reperfusion Injury Model
ABSTRACT

Background : The incidence of pulmonary complications after non-cardiac surgery compared to cardiac complications, namely 2.7% and 2.5%. Cause of this is oxidative stress, imbalance and endogenous oxygen radicals scavenging system. Lidocaine inhibits sodium channels and, reducing intracellular calcium intake, reducing the production of Reactive Oxygen Species (ROS) and modulation of mitochondrial bioenergetics, so expect lidocaine can increase levels of natural antioxidants in the cells.Superoxide Dismutase-1 (SOD-1) is a natural antioxidants in the cells having function to protecting organ from the dangerous anion superoxide which convert anion product from injury of ischaemiareperfusion.
Objective : To determine the effect of intravenous lidocaine on levels of superoxide dismutase 1 (SOD-1) with the rabbit lung ischemic reperfusion lung injury models.
Methods: An experimental design laboratory, 16 rabbits were divided into two groups randomly. The control group was treated lung ischemic reperfusion injury and the treatment group performed lung ischemic reperfusion injury and received injection of lidocaine 1,5mg / kg / hour continuous intravenous then measured the levels of SOD-1 lung tissue of both groups. Test for normality using Shapiro Wilk test followed different test Independent T-test.
Results: Levels of SOD-1 with the rabbit lung ischemic reperfusion lung injury and received lidocaine significantly higher (p = 0.01) compared with SOD-1 with the rabbit lung ischemic reperfusion lung injury.
Conclusions: Continuous intravenous administration of lidocaine may increase levels of SOD-1 lung rabbits with lung ischemic reperfusion injury.

 

Keywords : Lung ischemic reperfusion injury, Lidocaine, SOD-1
ABSTRAK

Latar belakang :Angka kejadian komplikasi paru paska operasi non jantung dibandingkan dengan komplikasi jantung yaitu 2,7% dan 2,5%. Penyebab hal ini adalah stres oksidatif, ketidakseimbangan radikal oksigen dan endogenous scavenging system.Lidokain  menghambat saluran natrium dan, mengurangi masukan kalsium intraseluler, mengurangi produksi Reactive Oxygen Species (ROS) dan modulasi bioenergetika mitokondria, sehingga diharapkan lidokain mampu meningkatkan kadar antioksidan alami di dalam sel.Superoxide Dismutase-1 (SOD-1) adalah salah satu antioksidan alami didalam sel yang berperan dalam melindungi organ dari anion superoksida yang berbahaya dengan mengubah anion yang dihasilkan dari cedera setelah ischaemia-reperfusion.

Tujuan : Mengetahui efek lidokain intravena terhadap kadar Superoxide Dismutase 1 (SOD-1) paru kelinci dengan lung ischemic reperfusion injury model.

Metode : Desain eksperimental laboratorik, 16 kelinci dibagi menjadi dua kelompok secara acak. Kelompok kontrol mendapat perlakuan lung ischemic reperfusion injury dan kelompok perlakuan dilakukan lung ischemic reperfusion injurydan mendapat injeksi lidokain 1,5mg/kgBB/jam intravena secara kontinyu kemudian diukur kadar SOD-1 jaringan paru kedua kelompok. Uji normalitas menggunakan uji Shapiro Wilk dilanjutkan uji beda Independent T-test.

Hasil : Kadar SOD-1 paru kelinci dengan lung ischemic reperfusion injurydan mendapat lidokain lebih tinggi secara signifikan (p=0,01) dibandingkan dengan kadar SOD-1 paru kelinci dengan lung ischemic reperfusion injury

Kesimpulan : Pemberian lidokain kontinyu intravena dapat meningkatkan kadar SOD-1 paru kelinci dengan lung ischemic reperfusion injury.

 

Kata kunci : Lung ischemic reperfusion injury, Lidokain, SOD-1
Artikel Sekarang
Dipublikasi pada 01 November 2015
Penulis :
» Mohammad Arief Kurniawan
» Johan Arifin
» Taufik Eko Nugroho
Kategori : Penelitian
Berkas Artikel (PDF)
Dari Jurnal
Volume VII nomor 3, November 2015 Cover JAI
Daftar Isi | Berkas Full (PDF)

 

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