Perbedaan Pengaruh Pemberian Propofol Dan Etomidat Terhadap Agregasi Trombosit
ABSTRACT
Background: Perioperative bleeding is a serious and common problem in surgery. Induction anesthetic agent usage is known for the inhibition of platelet aggregation. Objective: To determine the difference effect of propofol and penthotal administration on platelet aggregation. Method: An experimental study on 40 patients who received general anesthesia. Samples were divided into two groups (n:20, each). The first group received propofol and the second group received etomidat as the induction anesthetic agent during the procedure, and five minutes post induction, with the rate of administration propofol 2,5 mg/ body weight, etomidat 0,3 mg/ body weight and O₂ : N₂O ratio 50% : 50%. A specimens were taken to the Clinical Pathology Laboratory for Platelet Aggregation testing. Statistical analyses were performed using Paired T-Test and Independent T-Test (with level of significance p<0,05). Result: The result showed significant difference in percentage of maximal platelet aggregation before and after the administration of propofol (p=0,001) and not significant for etomidat group (p=0,089). In the propofol and etomidat group, the mean percentage of maksimal platelet aggregation was 66,07 ± 18,04. Statistically, propofol caused less significant hypo aggregation of plateled compared to etomidate, with (p=0,053). Conclusion: Propofol significantly decreased the percentage of maximal plateled aggregation, however the difference was not significant between two experiment groups.
Keywords : Propofol, etomidate, ADP, platelet aggregation
ABSTRAK
Latar belakang penelitian: Perdarahan perioperatif merupakan masalah yang sering dihadapi dalam setiap operasi. Penggunaan obat anestesi induksi dikatakan mempunyai pengaruh dalam agregasi trombosit Tujuan: Untuk mengetahui perbedaan pengaruh pemberian propofol dan etomidat terhadap agregasi trombosit. Metode: Merupakan penelitian eksperimental pada 40 pasien yang menjalani anestesi umum. Penderita dibagi 2 kelompok (n=20), kelompok I menggunakan propofol dan kelompok II menggunakan etomidat, yang diberi sejak awal induksi dengan besar pemberian propofol 2,5 mg/kg intravena, etomidat 0,3 mg/kg intravena bersama O2 : N2O = 50% : 50%. Masing-masing kelompok akan diambil spesimen sebelum induksi dan 5 menit setelah induksi. Semua spesimen dibawa ke Laboratorium Patologi Klinik untuk dilakukan pemeriksaan Tes Agregasi Trombosit. Uji statistik menggunakan Paired T-Test dan Independent T-Test (dengan derajat kemaknaan <0.05). Hasil: Karakteristik data penderita maupun data variabel yang akan dibandingkan terdistribusi normal. Pada penelitian ini didapatkan perbedaan persen agregasi maksimal trombosit yang bermakna sebelum dan sesudah pemberian propofol (p=0,001) dan tidak bermakna untuk sebelum dan sesudah pemberian etomidat (p=0,089). Pada kelompok propofol didapatkan rerata persen agregasi maksimal trombosit 66,07±8,28 dan etomidat 56,29+18,04 dan menunjukkan perbedaan yang bermakna antara keduanya (p=0,053). Kesimpulan: Propofol secara bermakna menurunkan persen agregasi maksimal trombosit, dibandingkan etomidat.
Kata kunci : Propofol, etomidat, ADP, agregasi platelet
Artikel Sekarang
Dipublikasi pada 01 March 2011
Penulis :
» Sri Tabahhati
» Uripno Budiono
» Mohamad Sofyan Harahap
Kategori : Penelitian
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Volume III Nomor 01, Maret 2011 Cover JAI
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