Pengaruh Premedikasi Klonidin terhadap Interval Q-Tc dan Skor Rate Pressure Product pada Laringoskopi Intubasi
ABSTRACT
Background: Endotracheal intubation laryngoscopy is an act done in general
anesthesia. Laryngoscopy and intubation actions than can cause trauma, can also
cause cardiovascular changes in the form of increased blood pressure, increased heart
rate, increased scores rate pressure product (RPP) which increased cardiac oxygen
demand and Q-Tc interval prolongation by sympathetic stimulation caused by
laryngoscopy intubation. Role of clonidine premedication administration aims to
reduce cardiovascular changes of decreased blood pressure and decreased heart rate.
Objective: This study aimed to study the effect of oral clonidine tablets for blood
pressure, heart rate, Q-Tc interval and score rate pressure product (RPP) during
laryngoscopy intubation
Methods: Forty-eight subjects aged 14-40 years with ASA physical status I and II, with
no sign of trouble intubation were randomly divided into groups of clonidine (KI) and
the control group (K II). KI group get oral clonidine premedication 0.15 mg 2 hours
before surgery, while K2 placebo. Both groups received the same treatment as
laryngoscopy intubation. Blood pressure, heart rate, Q-Tc interval and RPP score is
calculated at 2 minutes post-induction, 2 min and 5 min after intubation laryngoscopy.
Results: heart rate, RPP Score and QTc intervals did not differ significantly between
the two groups. However blood pressure in the clonidine group was significantly lower
in the clonidine group
Conclusions: Premedication with oral clonidine 0.15 mg dose did not affect the Q-Tc
interval, RPP scores, and heart rate were significantly laryngoscopy intubation in
adult patients.
Keywords : laryngoscopy intubation, clonidine, Rate Pressure Product, QTC interval
ABSTRAK
Latar belakang: Laringoskopi intubasi endotrakea merupakan tindakan yang banyak
dilakukan pada anestesi umum tindakan laringoskopi dan intubasi selain dapat
menimbulkan trauma, juga dapat menimbulkan gejolak kardiovaskuler berupa
peningkatan tekanan darah, peningkatan laju jantung, peningkatan score rate
pressure product (RPP) yaitu peningkatan kebutuhan oksigen jantung dan
pemanjangan interval Q-Tc oleh stimulasi simpatik akibat laringoskopi intubasi
Peran pemberian premedikasi klonidin bertujuan untuk mengurangi gejolak
kardiovaskuler berupa penurunan tekanan darah dan penurunan laju jantung.
Tujuan: Penelitian ini bertujuan untuk mempelajari pengaruh pemberian klonidin
tablet oral terhadap tekanan darah, laju jantung, interval Q-Tc dan skor rate pressure
product (RPP) saat laringoskopi intubasi
Metode: Empat puluh delapan subjek berusia 14-40 tahun dengan status fisik ASA I
dan II, tanpa tanda kesulitan intubasi dibagi secara acak menjadi kelompok klonidin
(K I) dan kelompok kontrol (K II). Kelompok KI mendapatkan premedikasi klonidin
oral 0,15 mg 2 jam sebelum operasi sedangkan K2 mendapatkan plasebo. Kedua
kelompok mendapatkan perlakuan yang sama saat laringoskopi intubasi. Tekanan
darah, laju jantung, interval Q-Tc dan skor RPP dihitung pada 2 menit pasca induksi,
2 menit dan 5 menit pasca laringoskopi intubasi.
Hasil: Laju jantung, Skor RPP dan interval QTc tidak berbeda bermakna antara
kedua kelompok . Akan tetapi tekanan darah pada kelompok klonidin secara bermakna
lebih rendah pada kelompok klonidin
Simpulan : Premedikasi klonidin oral pada dosis 0,15 mg tidak mempengaruhi
interval Q-Tc, skor RPP, dan laju jantung secara bermakna pada laringoskopi
intubasi pasien dewasa.

 

Kata kunci : laringoskopi intubasi, klonidin, Rate Pressure Product, interval QTC
Artikel Sekarang
Dipublikasi pada 01 July 2013
Penulis :
» Fajrian Noor
» Soni Hidayat
» Witjaksono
» Uripno Budiono
Kategori : Penelitian
Berkas Artikel (PDF)
Dari Jurnal
Volume V Nomor 2, Juli 2013 Cover JAI
Daftar Isi | Berkas Full (PDF)

 

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