Pengaruh Induksi Propofol dan Ketamin terhadap Kadar Procalcitonin Plasma
ABSTRACT
Background: Procalcitonin used as one of the inflammatory response to infection.
Induction of anesthesia used drugs known to affect the increase in procalcitonin
Objective: Determine the effect of differences in propofol and ketamine on levels of
procalcitonin in general anesthesia
Method: a quasi experimental study on 16 subjects who performed general anesthesia.
The samples were divided into 2 groups each of 8 samples, group 1 and 2 get a dose of
propofol 2.5 mg / kg intravenous or ketamine 2 mg / kg intravenous as an anesthetic
induction drugs. anesthesia were mainained with O2 and N2O with a ratio of 50%:
50%. Subject blood samples were taken before induction, 4 hours and 24 hours
following induction.
Results: There were significant difference in procalcitonin levels before and after
treatment in the propofol group (K1) (p = 0.008) and no significant difference in the
ketamine group (K2) (p = 1,00). Procalcitonin levels amid values K1 and K2 were
0.175 ± 0.1 and 0.05 ± 0.05. Propofol causes marked elevated levels of procalcitonin
compared to ketamine (p = 0.053)
Conclusion: Propofol significantly increased procalcitonin levels compared to
ketamine
Keywords : propofol, ketamine, procalcitonin, general anesthesia
ABSTRAK
Latar belakang: Procalcitonin merupakan salah satu petanda respon inflamasi
terhadap infeksi. Obat induksi anestesi dapat mempengaruhi kadar procalcitonin
plasma.
Tujuan: Menilai pengaruh propofol dan ketamin terhadap kadar procalcitonin dalam
induksi general anestesi
Metode: Studi quasi experimental terhadap 16 subjek yang menjalani general
anestesi. Sampel dibagi menjadi grup 1 yang mendapatkan propofol dengan dosis
2,5 mg/kgbb intravena dan grup 2 yang mendapatkan ketamin dengan dosis 2 mg/kgbb
intravena sebagai obat induksi anestesi selama prosedur penelitian, anestesi rumatan
O2 dan N2O dengan rasio 50%:50%. Sampel darah subjek diambil sebelum induksi,
jam ke-4 dan jam ke -24.
Hasil: Didapatkan perbedaaan kadar procalcitonin bermakna sebelum dan sesudah
perlakuan pada kelompok propofol (K1) (p=0,008) dan perbedaan tidak bermakna
pada kelompok ketamin (K2) (p=1,00). Nilai tengah kadar procalcitonin K1 dan K2
adalah 0,175±0,1 dan 0,05±0,05. Propofol menyebabkan peningkatan kadar
procalcitonin lebih tinggi dibandingkan ketamin (p=0,053)
Kesimpulan : Propofol secara bermakna meningkatkan kadar procalcitonin
dibandingkan ketamin

 

Kata kunci : Propofol, ketamin, procalcitonin, induksi, general anestesi
Artikel Sekarang
Dipublikasi pada 01 July 2013
Penulis :
» Aunun Rofiq
» Johan Arifin
» Witjaksono
Kategori : Penelitian
Berkas Artikel (PDF)
Dari Jurnal
Volume V Nomor 2, Juli 2013 Cover JAI
Daftar Isi | Berkas Full (PDF)

 

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